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Leukemia. 2008 Feb;22(2):400-5. Epub 2007 Nov 8.

Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell.

Author information

1
Department of Neuropathology, University Hospital of Cologne, Cologne, Germany.

Abstract

To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal center B cells, (ii) to display a gene expression profile similar to systemic diffuse large B-cell lymphomas (DLBCLs) and (iii) to be in part assigned to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB) subtype of DLBCL.

PMID:
17989719
PMCID:
PMC6053313
DOI:
10.1038/sj.leu.2405019
[Indexed for MEDLINE]
Free PMC Article

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