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Bioorg Med Chem Lett. 2008 Jan 1;18(1):313-7. Epub 2007 Nov 7.

pH sensing in living cells using fluorescent microspheres.

Author information

1
Chemical Biology Section, School of Chemistry, University of Edinburgh, Joseph Black Building, West Mains Road, EH9 3JJ Edinburgh, United Kingdom.

Abstract

Intracellular pH in living cells is measured in real time at the single cell level using fluorescently covalently loaded microspheres as efficient carrier systems and stable sensors. The use of these sensors immobilized covalently onto polymeric particles allows analysis of intracellular pH flux over long period of time and eliminates the disadvantages such as dilution within the cell, elimination via leakage or compartmentalization.

PMID:
17988866
DOI:
10.1016/j.bmcl.2007.10.075
[Indexed for MEDLINE]

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