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Nat Struct Mol Biol. 2007 Nov;14(11):1017-24. Epub 2007 Nov 5.

Cross-regulation of histone modifications.

Author information

  • 1Program in Genes and Development, Department of Biochemistry and Molecular Biology and Center for Epigenetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

Abstract

Histones undergo several different post-translational modifications that control a variety of physiological processes. These covalent modifications show substantial cross-regulation, providing a wealth of regulatory potential. New insights into the communication between modifications on histones have emerged in recent years. This review assesses the current understanding of cross-regulation of histone modifications and identifies future questions to be addressed in this field.

PMID:
17984964
DOI:
10.1038/nsmb1307
[PubMed - indexed for MEDLINE]
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