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Alcohol Alcohol. 2008 Jan-Feb;43(1):70-2. Epub 2007 Nov 5.

Rivastigmine in Wernicke-Korsakoff's syndrome: five patients with rivastigmine showed no more improvement than five patients without rivastigmine.

Author information

1
Parnassia Groep, The Hague, The Netherlands. luykxj@parnassia.nl

Abstract

AIMS:

To evaluate whether rivastigmine, an achetylcholinesterase inhibitor (AChEl), may be effective in restoring memory in Wernicke-Korsakoff's syndrome (WKS).

METHODS:

Five patients treated with rivastigmine for a period of 6 months were compared with five matched control patients, who received 6 months' conventional treatment, but without rivastigmine. Memory tests were administered at baseline and after 6 months.

RESULTS:

Slight improvements were observed in both rivastigmine and control patients, but no significant differences in improvements were found between the study groups.

CONCLUSION:

Treatment with rivastigmine may not be effective in restoring memory in WKS patients.

PMID:
17984137
DOI:
10.1093/alcalc/agm158
[Indexed for MEDLINE]
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