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J Plast Reconstr Aesthet Surg. 2008 Dec;61(12):1472-8. Epub 2007 Nov 5.

Reduction mammaplasty is effective treatment according to two quality of life instruments. A prospective randomised clinical trial.

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Department of Plastic Surgery, Helsinki University Central Hospital, HUS, Finland.



Debate around reduction mammaplasty has continued due to lack of prospective randomised clinical trials (RCTs). Therefore, a prospective randomised clinical trial was designed to assess the effectiveness of reduction mammaplasty performed for symptomatic breast hypertrophy.


82 patients were randomised, 40 patients to the operative group, and 42 patients to the nonoperative group. Groups were examined at 0 and 6 months. Instruments used were the Short Form-36 quality of life questionnaire (SF-36), the 15D quality of life questionnaire, the Finnish Breast-Associated Symptoms questionnaire (FBAS), and the Finnish Pain Questionnaire (FPQ). Analysis of covariance (ANCOVA) was applied for instrumental data comparison.


29 patients in the operative group and 35 patients in the nonoperative group completed the study. Mean age was 46 years. At second examination, the utility index score (SF-6D) and the physical summary score of SF-36, the index score of 15D, the breast-associated symptoms score of FBAS, and the pain score of FPQ demonstrated high significant statistical (P<0.0001) and clinical difference between groups. For the mental summary score of SF-36 findings were less significant statistically and clinically.


Reduction mammaplasty results in significant improvement of quality of life and decrease in pain and breast-associated symptoms. Future studies should be focused on patient selection and justification of the treatment by comparing with other approved treatments.

[Indexed for MEDLINE]

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