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Clin Rheumatol. 2008 Jun;27(6):709-12. Epub 2007 Nov 3.

Frequency of HLA-B27 alleles in Brazilian patients with psoriatic arthritis.

Author information

1
Unit of Rheumatology-Department of Internal Medicine, State University of Campinas Faculty of Medical Sciences (FCM/UNICAMP), BarĂ£o Geraldo, Campinas-SP, CEP: 13081-970 Mail box 611, Brazil. pdsampaiobarros@uol.com.br

Abstract

This prospective study analyzed the frequency of HLA-B27 and its alleles in 102 Brazilian patients with psoriatic arthritis (PsA). The association of the HLA-B27 alleles with these variants was compared to a control healthy HLA-B27 positive group of 111 individuals. There was a predominance of male gender (59.8%), Caucasian race (89.2%), and negative HLA-B27 (79.4%) patients. Asymmetric oligoarthritis (62.7%) was the most frequently observed clinical PsA subgroup, followed by spondylitis (16.7%), and polyarthritis (15.7%). Male gender and the spondylitis subgroup were statistically associated to the positive HLA-B27, and the oligoarthritis subgroup was associated to the negative HLA-B27. Among the 21 HLA-B27-positive PsA patients, there was a significant prevalence of the HLA-B*2705 allele (90.5%), similar to that observed in the control group (80.2%); HLA-B*2703 and HLA-B*2707 were statistically associated to the control group.

PMID:
17982707
DOI:
10.1007/s10067-007-0770-3
[Indexed for MEDLINE]

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