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Nat Neurosci. 2007 Dec;10(12):1515-7. Epub 2007 Nov 4.

GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI.

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1
Department of Psychiatry, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany. george.northoff@medizin.uni-magdeburg.de

Abstract

The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level-dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA.

PMID:
17982452
DOI:
10.1038/nn2001
[Indexed for MEDLINE]
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