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Bioorg Med Chem Lett. 2008 Jan 1;18(1):324-8. Epub 2007 Oct 17.

Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR.

Author information

1
GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.

Abstract

The biphenyl amides are a novel series of p38 MAP kinase inhibitors. Structure-activity relationships of the series against p38alpha are discussed with reference to the X-ray crystal structure of an example. The series was optimised rapidly to a compound showing oral activity in an in vivo disease model.

PMID:
17981461
DOI:
10.1016/j.bmcl.2007.10.043
[Indexed for MEDLINE]

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