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Eur J Med Chem. 2008 Jul;43(7):1478-88. Epub 2007 Sep 29.

Syntheses of 4-(indole-3-yl)quinazolines: a new class of epidermal growth factor receptor tyrosine kinase inhibitors.

Author information

1
Freie Universität Berlin, Institut für Pharmazie, Berlin, Germany. anja.lueth@fu-berlin.de

Abstract

The epidermal growth factor (EGF) family of membrane receptors has been identified as a key element in the complex signaling network that is utilized by various classes of cell-surface receptors. The synthesis and pharmacological results of 4-(indole-3-yl)quinazolines are described. The synthesized compounds are new high potent EGFR-tyrosine kinase inhibitors with excellent cytotoxic properties at different cell lines. Furthermore the 4-(indole-3-yl)quinazolines show some tendencies to inhibit the HER-2 TK, too. Moreover this substance class has remarkable strong fluorescence properties.

PMID:
17981366
DOI:
10.1016/j.ejmech.2007.09.018
[Indexed for MEDLINE]

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