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Am J Obstet Gynecol. 2008 Jan;198(1):37.e1-8. Epub 2007 Nov 5.

Lycopene and other carotenoid intake in relation to risk of uterine leiomyomata.

Author information

1
Channing Laboratory, the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. kterry@hsph.harvard.edu

Abstract

OBJECTIVE:

Carotenoids have antioxidant properties and have been associated with reduced risks of some cancers. We hypothesized that carotenoid intake may reduce the risk of diagnosed uterine leiomyoma (UL).

STUDY DESIGN:

We evaluated the associations between dietary carotenoids and risk of diagnosed UL in 82,512 premenopausal women aged 26-46 years in 1991 in the Nurses' Health Study II over 10 years of follow-up. Diet was assessed every 4 years with a validated food frequency questionnaire, and incidence of UL was assessed biennially by questionnaire.

RESULTS:

Total lycopene intake was not associated with diagnosed UL risk. Intake of beta-carotene was associated with slightly increased risks of diagnosed UL; this association was restricted to current smokers (for highest vs lowest quintile, relative risk = 1.36, 95% confidence interval 1.05 to 1.76; P(trend) = .003).

CONCLUSION:

Overall, our findings do not suggest that carotenoids reduce the risk of diagnosed UL. Among current smokers, high intake of beta-carotene may slightly increase risk of diagnosed UL.

PMID:
17981250
PMCID:
PMC2390902
DOI:
10.1016/j.ajog.2007.05.033
[Indexed for MEDLINE]
Free PMC Article
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