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FEBS Lett. 2007 Nov 27;581(28):5445-53. Epub 2007 Nov 5.

PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C. elegans.

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1
Cell Dynamics Research Center, Department of Life Science, GIST, Gwangju 500-712, Republic of Korea.

Abstract

Inorganic pyrophosphatase (PPase) catalyzes the hydrolysis of inorganic pyrophosphate (PPi) into phosphate (Pi), which provides a thermodynamic driving force for important biosynthetic reactions. The nematode Caenorhabditis elegans gene C47E12.4 encodes a PPase (PYP-1) which shows 54% amino acid identity with human PPase. PYP-1 exhibits specific enzyme activity and is mainly expressed in the intestinal and nervous system. A null mutant of pyp-1 reveals a developmental arrest at early larval stages and exhibits gross defects in intestinal morphology and function. The larval arrest phenotype was successfully rescued by reintroduction of the pyp-1 gene, suggesting that PYP-1 is required for larval development and intestinal function in C. elegans.

PMID:
17981157
DOI:
10.1016/j.febslet.2007.10.047
[Indexed for MEDLINE]
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