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FEBS Lett. 2007 Nov 27;581(28):5440-4. Epub 2007 Nov 5.

Loss of putative tumor suppressor EI24/PIG8 confers resistance to etoposide.

Author information

1
Department of Microbiology, Cancer Research Center, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA.

Abstract

Expression of p53-target gene EI24/PIG8 is lost in invasive breast cancers, suggesting that EI24/PIG8 is a tumor suppressor that prevents tumor spreading, and partially mediates p53-attributed tumor suppressor activity. EI24/PIG8 also has pro-apoptotic activity indicating that loss of EI24/PIG8 may modulate sensitivity to chemotherapy. Here it is demonstrated that suppression of EI24/PIG8 in fibroblasts and breast cancer cells significantly inhibits the apoptotic response to etoposide treatment. These findings suggest that loss of EI24/PIG8 contributes significantly to resistance of cells to chemotherapeutic agents that function through p53, and identify the EI24/PIG8 status as a potentially new prognostic marker of chemotherapy responsiveness.

PMID:
17981155
PMCID:
PMC2128731
DOI:
10.1016/j.febslet.2007.10.046
[Indexed for MEDLINE]
Free PMC Article

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