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Cell. 2007 Nov 2;131(3):446-7.

SUMO teams up with ubiquitin to manage hypoxia.

Author information

1
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, UK. helle.ulrich@cancer.org.uk

Abstract

Hypoxia, a condition of severe oxygen shortage, induces a transcriptional response that is important for both normal embryonic development and the growth of tumors. In this issue, Cheng et al. (2007) describe how the stability of the major transcriptional regulator of the hypoxic response, HIF1alpha, is modulated by the interplay between the ubiquitin and the SUMO conjugation systems.

PMID:
17981111
DOI:
10.1016/j.cell.2007.10.026
[Indexed for MEDLINE]
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