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Cell. 2007 Nov 2;131(3):441-3.

Allosteric activation of a bacterial stress sensor.

Author information

1
Center for Structural Biology, Institute of Biomedicine, Tsinghua University, Beijing, China. structure@tsinghua.edu.cn

Abstract

In Gram-negative bacteria, envelope stress signals such as unfolded outer membrane proteins (OMP) activate the periplasmic protease DegS. This protease then triggers a cellular pathway to alleviate the stress. Now Sohn et al. (2007) show conclusively that inhibition of DegS is relieved allosterically by binding of the C-terminal sequences in unfolded OMPs to the PDZ domain of DegS.

PMID:
17981109
DOI:
10.1016/j.cell.2007.10.021
[Indexed for MEDLINE]
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