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Fertil Steril. 2008 Sep;90(3):521-7. Epub 2007 Nov 5.

Predictive value of pregnancy history in subfertile couples: results from a nationwide cohort study in the Netherlands.

Author information

1
Center for Reproductive Medicine, Academic Medical Center, Amsterdam, The Netherlands. j.w.vandersteeg@amc.uva.nl

Abstract

OBJECTIVE:

To assess whether pregnancy history can predict the occurrence of a spontaneous ongoing pregnancy in subfertile couples.

DESIGN:

Prospective cohort study.

SETTING:

Thirty fertility centers in the Netherlands.

PATIENT(S):

Subfertile, ovulatory women with at least one patent tube and male partners without severely impaired semen quality.

INTERVENTION(S):

Fertility work-up, including a detailed pregnancy history.

MAIN OUTCOME MEASURE(S):

Spontaneous ongoing pregnancy.

RESULT(S):

We included 4445 couples, of whom 793 (18%) had a spontaneous ongoing pregnancy within 1 year of follow-up. Previous live birth and miscarriage in current partnership were both associated with higher fecundity as compared with primary infertility (hazard rate ratios for spontaneous pregnancy [HR] 1.4; 95% CI, 1.2-1.7 and 1.3; 95% CI, 1.0-1.5, respectively). Pregnancies in a woman's previous partnerships did not affect the fecundity of the couple. A pregnancy in a previous partnership of the male partner was associated with lower fecundity (HR 0.76; 95% CI, 0.58-0.99). A previous pregnancy after fertility treatment also was associated with lower fecundity (HR 0.52; 95% CI, 0.30-0.90).

CONCLUSION(S):

Accurate prediction of the future fertility of a couple requires an exact assessment of the fertility history of both partners.

[Indexed for MEDLINE]

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