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J Am Coll Cardiol. 2007 Nov 6;50(19):1822-34. Epub 2007 Oct 23.

Platelet function monitoring in patients with coronary artery disease.

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Sinai Center for Thrombosis Research, Sinai Hospital of Baltimore, Baltimore, Maryland, USA.


Studies focused on patient responsiveness to antiplatelet therapies, particularly aspirin and clopidogrel, have increased in recent years. However, the relations of in vivo platelet function and adverse clinical events to results of ex vivo platelet function tests remain largely unknown. This article describes current methods of measuring platelet function in various clinical and research situations and their advantages and disadvantages, reviews evidence for antiplatelet response variability and resistance, discusses the potential pitfalls of monitoring platelet function, and demonstrates emerging data supporting the positive clinical and treatment implications of platelet function testing.

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