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J Am Geriatr Soc. 2007 Nov;55(11):1786-92.

Serum calcium and cognitive function in old age.

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1
Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands.

Abstract

OBJECTIVES:

To determine whether serum calcium is associated with cognitive function in elderly individuals in the general population.

DESIGN:

Prospective follow-up study of two independent, population-based cohorts.

SETTING:

The Rotterdam Study (median follow-up 11 years) and the Leiden 85-plus Study (median follow-up 5 years).

PARTICIPANTS:

Three thousand nine hundred ninety-four individuals, mean age 71, from the Rotterdam Study and 560 individuals, all aged 85, from the Leiden 85-plus Study.

MEASUREMENTS:

Global cognitive function was assessed in both cohorts using the Mini-Mental State Examination; attention, psychomotor speed, and memory function were assessed in the Leiden 85-plus Study only. Linear regression and linear mixed models were used for statistical analyses.

RESULTS:

In the Rotterdam Study, high serum calcium was associated with worse global cognitive function at baseline (P<.05) and a faster rate of decline in cognitive function during follow-up (P=.005) in individuals aged 75 and older but not in younger individuals. In the Leiden 85-plus Study, high serum calcium was associated with worse global cognitive function from age 85 through 90 (P<.001). This observation also held for the specific cognitive domains tested (all P<.01). These results did not change when individuals with serum calcium levels greater than normal (>2.55 mmol/L) were excluded from the analyses.

CONCLUSION:

In the general population, high serum calcium levels are associated with faster decline in cognitive function over the age of 75.

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