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Curr Cancer Drug Targets. 2007 Jun;7(4):317-24.

AP-1 a target for cancer prevention.

Author information

1
Laboratory of Cancer Prevention, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA.

Abstract

The transcription factor activator protein 1 (AP-1) plays a pivotal role in tumorigenesis. AP-1 activity is increased in multiple human tumor types. Inhibitors of AP-1 have been shown to block tumor promotion, transformation, progression and invasion. Chronic inflammation and tumor development are linked. AP-1 may act, in part, by perpetuating the inflammatory signal. AP-1 is a recognized molecular target of many antioxidant and anti-inflammatory chemopreventive compounds. This review focuses on the AP-1 family proteins as targets for chemoprevention.

PMID:
17979626
DOI:
10.2174/156800907780809723
[Indexed for MEDLINE]

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