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Trends Mol Med. 2007 Nov;13(11):492-501. Epub 2007 Oct 30.

TGFbeta1 and Treg cells: alliance for tolerance.

Author information

1
BIO5 Institute, University of Arizona, PO Box 245217, Tucson, AZ 85724-5217, USA. ramiredb@email.arizona.edu

Abstract

Transforming growth factor beta1 (TGFbeta1), an important pleiotropic, immunoregulatory cytokine, uses distinct signaling mechanisms in lymphocytes to affect T-cell homeostasis, regulatory T (Treg)-cell and effector-cell function and tumorigenesis. Defects in TGFbeta1 expression or its signaling in T cells correlate with the onset of several autoimmune diseases. TGFbeta1 prevents abnormal T-cell activation through the modulation of Ca2+-calcineurin signaling in a Caenorhabditis elegans Sma and Drosophila Mad proteins (SMAD)3 and SMAD4-independent manner; however, in Treg cells, its effects are mediated, at least in part, through SMAD signaling. TGFbeta1 also acts as a pro-inflammatory cytokine and induces interleukin (IL)-17-producing pathogenic T-helper cells (Th IL-17 cells) synergistically during an inflammatory response in which IL-6 is produced. Here, we will review TGFbeta1 and its signaling in T cells with an emphasis on the regulatory arm of immune tolerance.

PMID:
17977791
PMCID:
PMC2805009
DOI:
10.1016/j.molmed.2007.08.005
[Indexed for MEDLINE]
Free PMC Article

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