Format

Send to

Choose Destination
Crit Rev Oncol Hematol. 2008 May;66(2):91-8. Epub 2007 Oct 31.

Role of insulin-like growth factor-1R system in colorectal carcinogenesis.

Author information

1
Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Building 10/12N226, Bethesda, MD 20892, United States.

Abstract

The insulin-like growth factor (IGF) system is comprised of receptors, ligands (IGF-I and IGF-II), and a family of binding proteins (IGFBPs). It plays an important role in growth and development and in the maintenance of normal homeostasis. We present a review of the current laboratory and epidemiologic evidence that suggests an important role of the IGF system in colorectal carcinogenesis. Due to the complexity of this system, we have focused the review on the role of the IGF-1 receptor and its ligands in colorectal carcinogenesis and the strategies to block this pathway as a potential anti-cancer therapy.

PMID:
17977741
PMCID:
PMC2374741
DOI:
10.1016/j.critrevonc.2007.09.003
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center