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Parkinsonism Relat Disord. 2008;14(4):342-4. Epub 2007 Oct 31.

CSF hypocretin-1 levels are normal in multiple-system atrophy.

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Institute of Neurology, Department of Neurology, Radboud University Nijmegen Medical Centre, 830 LKN, P.O. Box 9101, 6500 Nijmegan, HB, The Netherlands.


Sleep disturbances occur in 70% of the patients with multiple system atrophy (MSA). Disturbances of the hypothalamic hypocretin neurotransmission have been suggested as a possible cause. Since a systematic study of CSF hypocretin-1 levels in MSA has not yet been performed, we analysed CSF hypocretin-1 concentrations in 6 MSA-P and 6 MSA-C patients and 11 age-matched controls. We did not observe any differences from control values.

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