Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2007 Dec 15;17(24):6691-6. Epub 2007 Oct 22.

Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route.

Author information

1
Pfizer Global Research & Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.

Abstract

This paper reports the synthesis and biological activity of a novel series of aryl-morpholine dopamine receptor agonists. Several compounds show high levels of functional selectivity for the D3 over the D2 dopamine receptor. Compound 26 has >1000-fold functional selectivity and has been successfully progressed in vivo using an intranasal delivery route.

PMID:
17976986
DOI:
10.1016/j.bmcl.2007.10.059
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center