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FEBS Lett. 2007 Nov 27;581(28):5401-6. Epub 2007 Oct 30.

Endoplasmic reticulum association and N-linked glycosylation of the human Nrf3 transcription factor.

Author information

1
Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada.

Abstract

We have analysed the molecular and cellular regulation of the basic-leucine zipper (bZIP) transcription factor Nrf3 (NFE2-Related Factor 3). Cycloheximide studies revealed a rapid turnover of Nrf3. We showed that the proteasome inhibitor MG-132 increases Nrf3 protein levels. Furthermore, we demonstrated that Nrf3 is an N-glycosylated protein associated with the endoplasmic reticulum. Thus, our studies provide the first evidence of a post-translational modification of Nrf3.

PMID:
17976382
DOI:
10.1016/j.febslet.2007.10.041
[Indexed for MEDLINE]
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