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J Am Vet Med Assoc. 2007 Nov 1;231(9):1386-9.

Efficacy of bovine herpesvirus-1 inactivated vaccine against abortion and stillbirth in pregnant heifers.

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1
Rural Technologies Inc, 1008 32nd Ave, Brookings, SD 57006, USA.

Abstract

OBJECTIVE:

To evaluate the efficacy of an inactivated bovine herpesvirus-1 (BHV-1) vaccine to protect against BHV-1 challenge-induced abortion and stillbirth.

DESIGN:

Prospective study.

ANIMALS:

35 beef heifers.

PROCEDURES:

Before breeding, heifers were vaccinated with a commercially available BHV-1 inactivated vaccine SC or IM. The estrous cycle was then synchronized, and heifers were artificially inseminated 30 to 60 days after vaccination. Heifers (n = 21) were challenge inoculated IV at approximately 180 days of gestation with virulent BHV-1. Fourteen control heifers were not vaccinated. Clinical signs of BHV-1 infection were monitored for 10 days following challenge; serologic status and occurrence of abortion or stillbirth were evaluated until time of calving.

RESULTS:

18 of 21 (85.7%) heifers that received vaccine were protected from abortion following challenge, whereas all 14 control heifers aborted.

CONCLUSIONS AND CLINICAL RELEVANCE:

Results indicated that an inactivated BHV-1 vaccine can protect against abortion resulting from a substantial challenge infection, with efficacy similar to that of modified-live BHV-1 vaccines.

PMID:
17976001
DOI:
10.2460/javma.231.9.1386
[Indexed for MEDLINE]
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