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J Am Vet Med Assoc. 2007 Nov 1;231(9):1347-53.

Clinical assessment of repeated propofol-associated anesthesia in cats.

Author information

1
Section of Diagnostic Imaging and Radiation Oncology, Vetsuisse Faculty, University of Zurich, CH-8006 Zurich, Switzerland.

Abstract

OBJECTIVE:

To assess the effects of repeated episodes of propofol-associated anesthesia on quality of recovery from anesthesia, clinical status, and erythrocyte physiology in cats.

DESIGN:

Original study.

ANIMALS:

37 cats undergoing short-duration anesthesia for radiotherapy.

PROCEDURES:

Twice daily on 5 consecutive days, 13 cats with squamous cell carcinoma of the nasal planum (group 1) underwent anesthesia: first via administration of propofol or a midazolam (0.2 mg/kg [0.09 mg/lb])-propofol combination and then via administration of ketamine and midazolam each day (latter data were not analyzed). During a 19-day period, 24 cats with vaccine associated sarcoma (group 2) were anesthetized 12 times with propofol or a midazolam-propofol combination. Anesthesia was maintained with propofol in both groups. Hematologic analysis was performed before, during, and on completion of radiotherapy; changes in Hct and hemoglobin concentration between groups were compared.

RESULTS:

Mean duration of anesthesia was 8.1 minutes (range, 5 to 20 minutes); no adverse events were detected during recovery. Total dose of propofol administered did not differ between groups 1 (6.34 mg/kg [2.88 mg/lb]) and 2 (4.71 mg/kg [2.14 mg/lb]). Midazolam administration decreased the propofol dose by 26%. Overall decreases from baseline in Hct and hemoglobin concentration were not significantly different between the 2 groups, nor clinically important; however, compared with baseline, values in group 2 were significantly lower after 6 and 12 anesthetic episodes for both protocols. Heinz bodies were identified in low numbers in both groups during radiotherapy.

CONCLUSIONS AND CLINICAL RELEVANCE:

Results indicated that repeated propofol-associated short-duration anesthesia does not lead to clinically relevant hematologic changes in cats undergoing short-duration radiotherapy.

PMID:
17975992
DOI:
10.2460/javma.231.9.1347
[Indexed for MEDLINE]

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