Format

Send to

Choose Destination
Science. 2007 Nov 2;318(5851):794-7.

A gene regulatory network subcircuit drives a dynamic pattern of gene expression.

Author information

1
Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125, USA.

Abstract

Early specification of endomesodermal territories in the sea urchin embryo depends on a moving torus of regulatory gene expression. We show how this dynamic patterning function is encoded in a gene regulatory network (GRN) subcircuit that includes the otx, wnt8, and blimp1 genes, the cis-regulatory control systems of which have all been experimentally defined. A cis-regulatory reconstruction experiment revealed that blimp1 autorepression accounts for progressive extinction of expression in the center of the torus, whereas its outward expansion follows reception of the Wnt8 ligand by adjacent cells. GRN circuitry thus controls not only static spatial assignment in development but also dynamic regulatory patterning.

PMID:
17975065
DOI:
10.1126/science.1146524
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center