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The receptor of the type I interferon family.

Author information

1
CNRS UMR 5124, University Montpellier II, Place Eugène Bataillon, 34095 Montpellier 5, France. uze@univ-montp2.fr

Abstract

All type I IFNs act through a single cell surface receptor composed of the IFNAR1 and IFNAR2 subunits and two associated cytoplasmic tyrosine kinases of the Janus family, Tyk2 and Jak1. A central issue in type I IFN biology is to understand how a multitude of subtypes can generate similar signaling outputs but also govern specific cellular responses. This review summarizes results from the last decade that contributed to our current state of knowledge of IFN-receptor complex structure and assembly.

PMID:
17969444
[Indexed for MEDLINE]

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