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Antimicrob Agents Chemother. 2008 Jan;52(1):329-32. Epub 2007 Oct 29.

Human immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to Zidovudine and other nucleoside analog inhibitors in vitro.

Author information

1
University of Washington, Department of Pathology, K-046 HSB, Box 357705, 1959 NE Pacific St., Seattle, WA 98195, USA. smithra@u.washington.edu.

Abstract

Using an indicator cell assay that directly quantifies viral replication, we show that human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2, respectively) exhibit similar sensitivities to 3'-azido-3'-deoxythymidine (zidovudine) as well as other nucleoside analog inhibitors of reverse transcriptase. These data support the use of nucleoside analogs for antiviral therapy of HIV-2 infection.

PMID:
17967913
PMCID:
PMC2223890
DOI:
10.1128/AAC.01004-07
[Indexed for MEDLINE]
Free PMC Article

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