Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Chem Biol. 2007 Dec;11(6):620-5. Epub 2007 Nov 9.

Fluorescent probes for nitric oxide and hydrogen peroxide in cell signaling.

Author information

1
Department of Chemistry, University of California, Berkeley, CA 94720, USA.

Abstract

Nitric oxide (NO) and hydrogen peroxide (H(2)O(2)) have emerged as essential small molecules for cellular signal transduction owing largely to their ability to mediate oxidative posttranslational modifications (PTMs). Inventing new ways to track these small, diffusible, and reactive species with spatial and temporal resolution is a key challenge in elucidating their chemistry in living systems. Recent progress in the development of fluorescent probes that respond selectively to NO and H(2)O(2) produced at cell signaling levels offers a promising approach to interrogating their physiological production, accumulation, trafficking, and function.

PMID:
17967434
PMCID:
PMC2693042
DOI:
10.1016/j.cbpa.2007.09.018
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center