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Curr Opin Chem Biol. 2007 Dec;11(6):595-603. Epub 2007 Nov 9.

Knotted and topologically complex proteins as models for studying folding and stability.

Author information

1
UCLA Department of Chemistry and Biochemistry, Los Angeles, CA 90095-1569, USA. yeates@mbi.ucla.edu

Abstract

Among proteins of known three-dimensional structure, only a few possess complex topological features such as knotted or interlinked (catenated) protein backbones. Such unusual proteins offer potentially unique insights into folding pathways and stabilization mechanisms. They also present special challenges for both theorists and computational scientists interested in understanding and predicting protein-folding behavior. Here, we review complex topological features in proteins with a focus on recent progress on the identification and characterization of knotted and interlinked protein systems. Also, an approach is described for designing an expanded set of knotted proteins.

PMID:
17967433
PMCID:
PMC2179896
DOI:
10.1016/j.cbpa.2007.10.002
[Indexed for MEDLINE]
Free PMC Article
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