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Nat Neurosci. 2007 Dec;10(12):1587-93. Epub 2007 Oct 28.

Function of the Drosophila CPEB protein Orb2 in long-term courtship memory.

Author information

1
Research Institute of Molecular Pathology, Dr. Bohr-gasse 7, A-1030 Vienna, Austria. keleman@imp.ac.at

Abstract

Both long-term behavioral memory and synaptic plasticity require protein synthesis, some of which may occur locally at specific synapses. Cytoplasmic polyadenylation element-binding (CPEB) proteins are thought to contribute to the local protein synthesis that underlies long-term changes in synaptic efficacy, but a role has not been established for them in the formation of long-term behavioral memory. We found that the Drosophila melanogaster CPEB protein Orb2 is acutely required for long-term conditioning of male courtship behavior. Deletion of the N-terminal glutamine-rich region of Orb2 resulted in flies that were impaired in their ability to form long-term, but not short-term, memory. Memory was restored by expressing Orb2 selectively in fruitless (fru)-positive gamma neurons of the mushroom bodies and by providing Orb2 function in mushroom bodies only during and shortly after training. Our data thus demonstrate that a CPEB protein is important in long-term memory and map the molecular, spatial and temporal requirements for its function in memory formation.

PMID:
17965711
DOI:
10.1038/nn1996
[Indexed for MEDLINE]

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