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Trends Genet. 2007 Nov;23(11):539-42. Epub 2007 Oct 26.

Crossover interference underlies sex differences in recombination rates.

Author information

1
Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, ME 04609, USA. Petko.Petkov@jax.org

Abstract

In many organisms, recombination rates differ between the two sexes. Here we show that in mice, this is because of a shorter genomic interference distance in females than in males, measured in Mb. However, the interference distance is the same in terms of bivalent length. We propose a model in which the interference distance in the two sexes reflects the compaction of chromosomes at the pachytene stage of meiosis.

PMID:
17964681
DOI:
10.1016/j.tig.2007.08.015
[Indexed for MEDLINE]

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