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Diagn Microbiol Infect Dis. 2008 Feb;60(2):229-31. Epub 2007 Oct 25.

Preexisting antibodies to homologous colonization factors and heat-labile toxin in serum, and the risk to develop enterotoxigenic Escherichia coli-associated diarrhea.

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Institute of Biomedicine, Department of Microbiology and Immunology, The Sahlgrenska Academy of Göteborg University, S-40530 Göteborg, Sweden.


Preexisting serum immunoglobulin (Ig) A and IgG titers against colonization factors and heat-labile toxin of enterotoxigenic Escherichia coli (ETEC) were examined in young adults who subsequently developed ETEC-associated diarrhea and in healthy matched controls. The data suggest an inverse association between the antibody titers against colonization factors, but not heat-labile toxin, and development of ETEC-associated diarrhea.

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