Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Parasitol. 2007 Dec;23(12):589-95. Epub 2007 Oct 24.

Target assessment for antiparasitic drug discovery.

Author information

1
Drug Discovery Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

Abstract

Drug discovery is a high-risk, expensive and lengthy process taking at least 12 years and costing upwards of US$500 million per drug to reach the clinic. For neglected diseases, the drug discovery process is driven by medical need and guided by pre-defined target product profiles. Assessment and prioritisation of the most promising targets for entry into screening programmes is crucial for maximising the chances of success. Here, we describe criteria used in our drug discovery unit for target assessment and introduce the 'traffic-light' system as a prioritisation and management tool. We hope this brief review will stimulate basic scientists to acquire additional information necessary for drug discovery.

PMID:
17962072
PMCID:
PMC2979298
DOI:
10.1016/j.pt.2007.08.019
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center