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Biochim Biophys Acta. 2008 Mar;1778(3):794-809. Epub 2007 Sep 15.

Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis.

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1
Vascular Pathophysiology Laboratory, Inserm U882 38054 Grenoble, France.

Abstract

Endothelial cells lining the vessel wall are connected by adherens, tight and gap junctions. These junctional complexes are related to those found at epithelial junctions but with notable changes in terms of specific molecules and organization. Endothelial junctional proteins play important roles in tissue integrity but also in vascular permeability, leukocyte extravasation and angiogenesis. In this review, we will focus on specific mechanisms of endothelial tight and adherens junctions.

PMID:
17961505
DOI:
10.1016/j.bbamem.2007.09.003
[Indexed for MEDLINE]
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