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Acc Chem Res. 2007 Dec;40(12):1309-19. Epub 2007 Oct 26.

Hydrogenation processes in the synthesis of perfumery ingredients.

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Synthesis, Corporate R&D Division, Firmenich SA, PO Box 239, CH-1211 Geneva 8, Switzerland.


Homogeneous catalytic hydrogenation has played an important role in the development of modern organic synthesis. Indeed, the discovery of highly regio- and stereoselective catalysts for C=C and C=O bonds reductions has allowed the efficient synthesis of optically active compounds. As the fragrance industry has turned to synthetic ingredients to fulfill the need for novel, cost-effective, and environment-friendly products, the use of catalytic processes are more and more in demand. In this Account, we thus highlight the application of catalytic hydrogenation in the synthesis of fragrance ingredients.


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