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Mov Disord. 2008 Jan;23(1):118-22.

Adult-onset Alexander disease with progressive ataxia and palatal tremor.

Author information

1
Department of Neurology, University of Colorado at Denver Health Sciences Center, Denver, Colorado 80262, USA. Katherine.Howard@UCHSC.edu

Abstract

A novel glial fibrillary acidic protein (GFAP) mutation, Y257C, is reported in a patient with adult-onset Alexander disease. This is the oldest reported case with confirmation of a GFAP mutation. Onset was late in the sixth decade. Genetic analysis of the GFAP gene is recommended in cases of progressive ataxia and palatal tremor.

PMID:
17960815
DOI:
10.1002/mds.21774
[Indexed for MEDLINE]

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