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Microb Pathog. 2008 Mar;44(3):255-61. Epub 2007 Sep 26.

Glutathione levels and immune responses in tuberculosis patients.

Author information

1
Division of Infectious Diseases, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA. venketvi@gmail.com

Abstract

Glutathione levels are significantly reduced in peripheral blood mononuclear cells and red blood cells isolated from tuberculosis patients. Treatment of blood cultures from tuberculosis patients with N-acetyl cysteine, a glutathione precursor, was associated with improved control of intracellular M. tuberculosis infection. N-acetyl-cysteine treatment decreased the levels of IL-10, IL-6, TNF-alpha and IL-1, in blood cultures derived from tuberculosis patients, favoring the host immune cells to successfully control M. tuberculosis replication.

PMID:
17959342
DOI:
10.1016/j.micpath.2007.09.002
[Indexed for MEDLINE]

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