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Neurosci Lett. 1991 Sep 16;130(2):141-4.

Sleep homeostasis in the rat: simulation of the time course of EEG slow-wave activity.

Author information

1
Institute of Pharmacology, University of Zürich, Switzerland.

Erratum in

  • Neurosci Lett 1991 Nov 11;132(2):279.

Abstract

According to the two-process model of sleep regulation, a homeostatic Process S increases during waking and declines during sleep. For humans, the time course of S has been derived from the changes in EEG slow-wave activity (SWA; spectral power density in the 0.75-4.0 Hz range) during sleep. We tested the applicability of the model to sleep in the rat. The simulation was based on the vigilance states for consecutive 8-s epochs of a 96-h experiment in 9 animals. The level of S was made to decrease in epochs of non-REM sleep (NREMS), and to increase in epochs of waking or REM sleep according to exponential functions. By optimizing the initial value and the time constants of S, a close fit between the hourly values of SWA in NREMS and of S was obtained. The biphasic time course of SWA during baseline, its enhancement in the initial recovery period after 24-h sleep deprivation, and its subsequent prolonged undershoot were present in the simulation. We conclude that sleep homeostasis as conceptualized in the two-process model may be a general property of mammalian sleep.

PMID:
1795873
DOI:
10.1016/0304-3940(91)90382-4
[Indexed for MEDLINE]

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