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Nutr Rev. 2007 Sep;65(9):412-5.

Eat less, live longer? New insights into the role of caloric restriction in the brain.

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Florida State University, Program in Neuroscience, Department of Nutrition, Food and Exercise Sciences, 237 Biomedical Research Facility, Tallahassee, FL 32306-4340, USA.


Caloric restriction has wide-ranging health benefits and may offer protection against age-related neuronal loss and neurodegenerative disorders such as Alzheimer's disease, possibly via enhanced adult neurogenesis. While a variety of interventions such as exercise increase neurogenesis, recent work suggests that exercise and caloric restriction may work to enhance neurogenesis by different neurobiological mechanisms, suggesting a role for both diet and exercise in disease prevention.

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