Format

Send to

Choose Destination
Acta Neurobiol Exp (Wars). 2007;67(3):207-18.

Vesicular glutamate transporters (VGLUTs): the three musketeers of glutamatergic system.

Author information

1
Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland. m.liguz@nencki.gov.pl

Abstract

Glutamate is the predominant excitatory neurotransmitter in the central nervous system (CNS) and glutamatergic transmission is critical for controlling neuronal activity. Glutamate is stored in synaptic vesicles and released upon stimulation. The homeostasis of glutamatergic system is maintained by a set of transporters present in plasma membrane and in the membrane of synaptic vesicles. The family of vesicular glutamate transporters in mammals is comprised of three highly homologous proteins: VGLUT1-3. The expression of particular VGLUTs is largely complementary with limited overlap and so far they are most specific markers for neurons that use glutamate as neurotransmitter. VGLUTs are regulated developmentally and determine functionally distinct populations of glutamatergic neurons. Controlling the activity of these proteins could potentially modulate the efficiency of excitatory neurotransmission. This review summarizes the recent knowledge concerning molecular and functional characteristic of vesicular glutamate transporters, their development, contribution to synaptic plasticity and their involvement in pathology of the nervous system.

PMID:
17957901
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Nencki Institute of Experimental Biology and Polish Neuroscience Society
Loading ...
Support Center