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Chem Commun (Camb). 2007 Nov 14;(42):4366-8. Epub 2007 Aug 13.

Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex.

Author information

1
Department of Chemistry, Imperial College London, London, UK SW7 2AZ.

Abstract

Two new mono-substituted phenanthroline ligands and their platinum(II) square planar complexes have been prepared; one of the complexes has been shown to induce a high degree of quadruplex DNA stabilisation and to inhibit telomerase.

PMID:
17957288
DOI:
10.1039/b709898g
[Indexed for MEDLINE]

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