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Cell. 2007 Oct 19;131(2):223-5.

A backup DNA repair pathway moves to the forefront.

Author information

1
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. andre_nussenzwweig@nih.gov

Abstract

Chromosomal translocations between antigen receptor loci and oncogenes are a hallmark of lymphoid cancers. Several new studies now reveal that programmed DNA breaks created during assembly of antigen receptor genes can be channeled into an alternative DNA end-joining pathway that is implicated in the chromosomal translocations of lymphoid cancers (Corneo et al., 2007; Soulas-Sprauel et al., 2007; Yan et al., 2007).

PMID:
17956720
DOI:
10.1016/j.cell.2007.10.005
[Indexed for MEDLINE]
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