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Biochem Soc Trans. 2007 Nov;35(Pt 5):974-9.

Protein-protein interactions in the assembly and subcellular trafficking of the BACE (beta-site amyloid precursor protein-cleaving enzyme) complex of Alzheimer's disease.

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1
Department of Basic Medical Sciences, St. George's, University of London, Cranmer Terrace, London SW17 0RE, U.K. r.parsons@sgul.ac.uk

Abstract

The correct assembly of the BACE (beta-site amyloid precursor protein-cleaving enzyme or beta-secretase) complex and its subsequent trafficking to cellular compartments where it associates with the APP (amyloid precursor protein) is essential for the production of Abeta (amyloid beta-peptide), the protein whose aggregation into senile plaques is thought to be responsible for the pathogenesis of AD (Alzheimer's disease). These processes rely upon both transient and permanent BACE-protein interactions. This review will discuss what is currently known about these BACE-protein interactions and how they may reveal novel therapeutic targets for the treatment of AD.

PMID:
17956258
DOI:
10.1042/BST0350974
[Indexed for MEDLINE]
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