Format

Send to

Choose Destination
See comment in PubMed Commons below
J Cell Biol. 2007 Oct 22;179(2):305-19.

Necdin mediates skeletal muscle regeneration by promoting myoblast survival and differentiation.

Author information

1
Department of Histology and Medical Embryology, University of Roma-La Sapienza, 00161 Rome, Italy.

Abstract

Regeneration of muscle fibers that are lost during pathological muscle degeneration or after injuries is sustained by the production of new myofibers. An important cell type involved in muscle regeneration is the satellite cell. Necdin is a protein expressed in satellite cell-derived myogenic precursors during perinatal growth. However, its function in myogenesis is not known. We compare transgenic mice that overexpress necdin in skeletal muscle with both wild-type and necdin null mice. After muscle injury the necdin null mice show a considerable defect in muscle healing, whereas mice that overexpress necdin show a substantial increase in myofiber regeneration. We also find that in muscle, necdin increases myogenin expression, accelerates differentiation, and counteracts myoblast apoptosis. Collectively, these data clarify the function and mechanism of necdin in skeletal muscle and show the importance of necdin in muscle regeneration.

PMID:
17954612
PMCID:
PMC2064766
DOI:
10.1083/jcb.200701027
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center