Format

Send to

Choose Destination
Curr Opin Pharmacol. 2007 Dec;7(6):570-4. Epub 2007 Oct 22.

Mechanisms of CCK signaling from gut to brain.

Author information

1
Department of Vet Med: Anatomy, Physiology and Cell Biology (APC), UC Davis School of Veterinary Medicine, Davis, CA 95616, USA. heraybould@ucdavis.edu

Abstract

Following the observation that exogenous peripheral injection of CCK could inhibit food intake, the mechanisms by which CCK influences the gut-brain pathway have been the subject of intense study for nearly 30 years. Recently, it has become evident that the system is more complex and that the consequences of CCK's action on the gut-brain pathway are more far reaching than previously recognized. This review will examine the recent evidence showing the role of CCK and CCK1Rs in modulating expression of other receptors for orexigenic and anorexigenic regulatory peptides at the level of vagal afferent neurons. In addition, new evidence showing the importance of the action of CCK at the level of the vagus nerve in the regulation of food intake, body weight, and in activation of an anti-inflammatory pathway will be reviewed.

PMID:
17954038
PMCID:
PMC2692370
DOI:
10.1016/j.coph.2007.09.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center