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Fertil Steril. 2008 Aug;90(2):315-21. Epub 2007 Oct 22.

Relationship between women's age and basal follicle-stimulating hormone levels with aneuploidy risk in in vitro fertilization treatment.

Author information

1
Lister Fertility Clinic, Lister Hospital, London, United Kingdom. mythum@doctors.net.uk

Abstract

OBJECTIVE:

To assess the relationship of age and basal FSH level to the genetic quality of the embryo and the association with IVF treatment outcome.

DESIGN:

Prospective observation study.

SETTING:

A major inner London fertility clinic in the United Kingdom.

PATIENT(S):

One hundred fifty-one women who underwent IVF treatment cycles in conjunction with preimplantation genetic diagnosis for aneuploidy screening before fresh embryo transfer, between July 2003 and July 2005.

INTERVENTION(S):

Basal FSH levels (days 2-4) were determined at an earlier cycle, and women were divided into two groups: high basal FSH (>or=10 IU/L) and low basal FSH (<10 IU/L). Chromosome analysis was performed on a single blastomere by using fluorescence in situ hybridization.

MAIN OUTCOME MEASURE(S):

Percentage of aneuploid embryos.

RESULT(S):

The percentage of aneuploid embryos was not statistically significantly different between the high- (50.0%, n = 32) and low- (50.2%, n = 119) basal FSH groups. However, the percentage of aneuploid embryos was statistically significantly higher (56.2%, n = 109) for women aged >or=38 years, as compared with women <38 years of age (37.5%, n = 42), independent of basal FSH levels.

CONCLUSION(S):

Elevated basal FSH levels reflect lower ovarian reserve but have no association with genetic quality of embryos. The percentage of aneuploid embryos is increased with advanced maternal age.

[Indexed for MEDLINE]

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