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Pharm Stat. 2008 Apr-Jun;7(2):142-6.

Issues with using baseline in last observation carried forward analysis.

Author information

1
Medical Statistics Group, University of Sheffield, Sheffield, UK. S.A.Julious@Sheffield.ac.uk

Abstract

The topic of this paper was prompted by a study for which one of us was the statistician. It was submitted to Annals of Internal Medicine. The paper had positive reviewer comment; however, the statistical reviewer stated that for the analysis to be acceptable for publication, the missing data had to be accounted for in the analysis through the use of baseline in a last observation carried forward imputation. We discuss the issues associated with this form of imputation and recommend that it should not be undertaken as a primary analysis.

PMID:
17952878
DOI:
10.1002/pst.311
[Indexed for MEDLINE]

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