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Bone Marrow Transplant. 2008 Feb;41(3):275-8. Epub 2007 Oct 22.

Ovarian recovery after stem cell transplantation.

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Department of Medicine, Moores University of California San Diego Cancer Center, University of California San Diego, San Diego, CA, USA.


Autologous or allogeneic SCT with conventional conditioning (chemotherapy with or without irradiation) has emerged as an effective and potentially curative therapy in patients with hematologic malignancies and in other selected solid tumors; however, several patients experience significant early and delayed side effects, including long-term endocrine imbalance and infertility. In spite of several reproductive recovery and pregnancy reports published in the oncology literature, review of medical literature reveals a paucity of comparable information in the SCT field. We report here four cases of ovarian recovery in patients who received hormonal replacement therapy after diagnosis of primary ovarian failure due to high-dose chemotherapy and SCT.

[Indexed for MEDLINE]

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