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J Bacteriol. 2007 Dec;189(24):9131-4. Epub 2007 Oct 19.

Transmembrane helix 12 of the Staphylococcus aureus multidrug transporter QacA lines the bivalent cationic drug binding pocket.

Author information

1
School of Biological Sciences, The University of Sydney, Sydney, New South Wales, Australia.

Abstract

An acidic residue in transmembrane segment (TMS) 10 is important for recognition of bivalent cationic substrates by the QacA multidrug transporter. Remarkably, an acidic residue in TMS 12 compensated for the absence of such a residue in TMS 10, suggesting that TMS 12 is a component of the bivalent cation-binding region.

PMID:
17951386
PMCID:
PMC2168635
DOI:
10.1128/JB.01492-07
[Indexed for MEDLINE]
Free PMC Article

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